The drive to transcend all limits
From Pynchon’s Prophecy, by Gus Mitchell:
Pynchon shows us that the drive to transcend all limits has constructed systems of another order. These systems, though based first on human networks of power and control, eventually exceed our individual and collective grasp, and take on a life, or rather an anti-life, of their own.
This appeals to the psychoanalyst in me because I think it is a very succinct way to describe the drive (i.e., the drive to transcend all limits) and its effects.